Anaplastic Large Cell Lymphoma and Vanishing Bile Duct Syndrome
نویسندگان
چکیده
A 39-year-old healthy man noticed a painful left chest wall mass associated with daily fevers, generalized pruritus, and jaundice. A hepatic panel showed a total bilirubin of 24.9 mg/dL, AST of 224 U/L, ALT of 506 U/L, and alkaline phosphatase of 1947 U/L. A chest computerized tomography (CT) showed a 9.6 x 5.2 cm chest wall mass extending to the mediastinum, and biopsy revealed anaplastic large cell lymphoma (ALCL). An abdominal CT showed normal liver parenchyma without ductal obstruction. Liver biopsy revealed bile duct damage, cholestasis, and hepatocyte injury (Figure 1).
منابع مشابه
Vanishing Bile Duct Syndrome in a Hodgkin's Lymphoma Patient with Fatal Outcome Despite Lymphoma Remission
Vanishing bile duct syndrome (VBDS) is a condition resulting from severe bile duct injury, progressive destruction, and disappearance of intrahepatic bile ducts (ductopenia) leading to cholestasis, biliary cirrhosis, and liver failure. VBDS can be associated with a variety of disorders, including Hodgkin's lymphoma (HL). We describe a 33-year-old male patient who presented with lymphadenopathy ...
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عنوان ژورنال:
دوره 3 شماره
صفحات -
تاریخ انتشار 2016